Unwanted impact of antibiotics broader, more complex than previously known | News & Research Communications | Oregon State University
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CORVALLIS, Ore. Researchers at Oregon State University have discovered that antibiotics have an impact on the microorganisms that live in an animal s gut that s more broad and complex than previously known.
Researchers have known for some time that antibiotics can have unwanted side effects, especially in disrupting the natural and beneficial microbiota of the gastrointestinal system. But the new study helps explain in much more detail why that is happening, and also suggests civil service jobs that powerful, long-term antibiotic use can have even more far-reaching effects.
Scientists now suspect that antibiotic use, and especially overuse, can have unwanted civil service jobs effects civil service jobs on everything from the immune system to glucose metabolism, food absorption, obesity, stress and behavior.
The issues are rising in importance, civil service jobs since 40 percent of all adults and 70 percent of all children take one or more antibiotics every year, not to mention their use in billions of food animals. Although when used properly civil service jobs antibiotics can help treat life-threatening bacterial civil service jobs infections, more than 10 percent of people who receive the medications can suffer from adverse side effects.
Just in the past decade a whole new universe has opened up about the far-reaching effects of antibiotic use, and now we re exploring it, said Andrey civil service jobs Morgun, an assistant professor civil service jobs in the OSU College of Pharmacy. The study of microbiota is just exploding. Nothing we find would surprise me at this point.
Prior to this most people thought antibiotics only depleted microbiota and diminished several important immune functions that take place in the gut, Morgun said. Actually that s only about one-third of the picture. They also kill intestinal epithelium. civil service jobs Destruction of the intestinal civil service jobs epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health.
The research also found that antibiotics civil service jobs and antibiotic-resistant microbes caused significant changes in mitochondrial function, which in turn can lead to more epithelial cell death. That antibiotics have special impacts on the mitochondria of cells is both important and interesting, said Morgun, who was a co-leader of this study with Dr. Natalia Shulzhenko, a researcher in the OSU College of Veterinary Medicine who has an M.D. from Kharkiv Medical University.
But the relationship of antibiotics to mitochondria civil service jobs may go back a long way. In evolution, mitochondria descended from bacteria, which were some of the earliest life forms, and different bacteria competed with each other for survival. That an antibiotic would still selectively attack the portion of a cell that most closely resembles bacteria may be a throwback to that ingrained civil service jobs sense of competition and the very evolution of life.
Digestive dysfunction is near the top of the list, with antibiotic use linked to such issues civil service jobs as diarrhea and ulcerative colitis. But new research is also finding links to obesity, food absorption, depression, immune function, sepsis, allergies and asthma.
This research also developed a new bioinformatics approach named transkingdom network interrogation to studying microbiota, which could help further speed the study of any alterations of host microbiota interactions and antibiotic impact. This could aid the search for new probiotics to help offset antibiotic effects, civil service jobs and conceivably lead to systems that would diagnose a person s microbiome, identify deficiencies and then address them in a precise and individual way.
Healthy microbiota may also be another way to address growing problems with antibiotic resistance, Morgun said. Instead of trying to kill the bad bacteria causing an illness, a healthy and functioning microbiota may be able to outcompete the unwanted microbes and improve immune function.
Collaborators on this research were from the OSU College of Pharmacy; OSU College of Veterinary Medicine; OSU College of Science; the National Cancer Institute; civil service jobs University of British Columbia; University of Maryland School of Medicine; and the National Institutes of Health.
agriculture and food athletics business and the economy campus life energy and sustainability engineering and technology environment and natural resources civil service jobs heath and nutrition international libraries and information technology marine science and the coast people programs civil service jobs and events portland scientific research and advances students
About Oregon State University: OSU is one of only two U.S. universities
News civil service jobs & Research Communications News Releases RSS Feeds For Journalists General University Experts civil service jobs Earthquake and Tsunami Experts Aging and Seniors Issues Experts civil service jobs For Faculty and Staff Photos and Multimedia Contact Us Calendar Library Maps Online Services civil service jobs Make a Gift
CORVALLIS, Ore. Researchers at Oregon State University have discovered that antibiotics have an impact on the microorganisms that live in an animal s gut that s more broad and complex than previously known.
Researchers have known for some time that antibiotics can have unwanted side effects, especially in disrupting the natural and beneficial microbiota of the gastrointestinal system. But the new study helps explain in much more detail why that is happening, and also suggests civil service jobs that powerful, long-term antibiotic use can have even more far-reaching effects.
Scientists now suspect that antibiotic use, and especially overuse, can have unwanted civil service jobs effects civil service jobs on everything from the immune system to glucose metabolism, food absorption, obesity, stress and behavior.
The issues are rising in importance, civil service jobs since 40 percent of all adults and 70 percent of all children take one or more antibiotics every year, not to mention their use in billions of food animals. Although when used properly civil service jobs antibiotics can help treat life-threatening bacterial civil service jobs infections, more than 10 percent of people who receive the medications can suffer from adverse side effects.
Just in the past decade a whole new universe has opened up about the far-reaching effects of antibiotic use, and now we re exploring it, said Andrey civil service jobs Morgun, an assistant professor civil service jobs in the OSU College of Pharmacy. The study of microbiota is just exploding. Nothing we find would surprise me at this point.
Prior to this most people thought antibiotics only depleted microbiota and diminished several important immune functions that take place in the gut, Morgun said. Actually that s only about one-third of the picture. They also kill intestinal epithelium. civil service jobs Destruction of the intestinal civil service jobs epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health.
The research also found that antibiotics civil service jobs and antibiotic-resistant microbes caused significant changes in mitochondrial function, which in turn can lead to more epithelial cell death. That antibiotics have special impacts on the mitochondria of cells is both important and interesting, said Morgun, who was a co-leader of this study with Dr. Natalia Shulzhenko, a researcher in the OSU College of Veterinary Medicine who has an M.D. from Kharkiv Medical University.
But the relationship of antibiotics to mitochondria civil service jobs may go back a long way. In evolution, mitochondria descended from bacteria, which were some of the earliest life forms, and different bacteria competed with each other for survival. That an antibiotic would still selectively attack the portion of a cell that most closely resembles bacteria may be a throwback to that ingrained civil service jobs sense of competition and the very evolution of life.
Digestive dysfunction is near the top of the list, with antibiotic use linked to such issues civil service jobs as diarrhea and ulcerative colitis. But new research is also finding links to obesity, food absorption, depression, immune function, sepsis, allergies and asthma.
This research also developed a new bioinformatics approach named transkingdom network interrogation to studying microbiota, which could help further speed the study of any alterations of host microbiota interactions and antibiotic impact. This could aid the search for new probiotics to help offset antibiotic effects, civil service jobs and conceivably lead to systems that would diagnose a person s microbiome, identify deficiencies and then address them in a precise and individual way.
Healthy microbiota may also be another way to address growing problems with antibiotic resistance, Morgun said. Instead of trying to kill the bad bacteria causing an illness, a healthy and functioning microbiota may be able to outcompete the unwanted microbes and improve immune function.
Collaborators on this research were from the OSU College of Pharmacy; OSU College of Veterinary Medicine; OSU College of Science; the National Cancer Institute; civil service jobs University of British Columbia; University of Maryland School of Medicine; and the National Institutes of Health.
agriculture and food athletics business and the economy campus life energy and sustainability engineering and technology environment and natural resources civil service jobs heath and nutrition international libraries and information technology marine science and the coast people programs civil service jobs and events portland scientific research and advances students
About Oregon State University: OSU is one of only two U.S. universities
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